Scientists at NNGU have found a way to enhance the effectiveness of anticancer drugs.

      Photo: press service of Nizhny Novgorod State University named after N.I. Lobachevsky (NNSU), author - Andrey Skvortsov

      An innovative method for synthesizing compounds to increase the activity of antitumor drugs has been developed at Nizhny Novgorod State University named after N.I. Lobachevsky (NNSU). This method allows adding booster fragments to already existing pharmaceutical drugs, the university's press service said.

      Scientists from the Department of Organic Chemistry of the Faculty of Chemistry have developed a technology for introducing aminomethyl groups into biologically active compounds that suppress the growth of tumor cells. This significantly increases the effectiveness of antitumor drugs.

      Vasily Otvagin, Associate Professor of the Department of Organic Chemistry, explained that in the 1980s these compounds were actively studied, but their chemical structure made them unstable and rapidly decomposing, which complicated their use. Zinc chloride was used to stabilize the synthesis process. The high yield and purity of the product make the method interesting for scientists and pharmaceutical production.

      Aminomethyl groups act as pharmacophoric fragments, enhancing the effectiveness of antitumor drugs. The new reaction allows adding these fragments to finished medicines.

      Ekaterina Kudryashova, Junior Researcher of the Department of Organic Chemistry, reported that the method is also used to synthesize new biologically active compounds, including substances with nitrogen-containing heterocycles, which may have significant biological activity. The method also allows one-stage attachment of peptides targeted at tumor cells.

      The research was carried out by scientists from the Faculty of Chemistry, the Research Institute of Chemistry and the Department of Biophysics of the Institute of Biology and Biomedicine of Lobachevsky University in cooperation with the Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences.

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      More news about the event:

      New method for synthesizing compounds to enhance the activity of antitumor drugs developed at NNSU

      The development allows adding booster fragments to finished pharmaceutical preparations

      Using the method, scientists of the Department of Organic Chemistry of the Faculty of Chemistry of Nizhny Novgorod State University named after N.I. Lobachevsky. 17:17 11.01.2026 NNSU - Nizhny Novgorod

      New method for synthesizing compounds to enhance the activity of antitumor drugs developed at NNSU

      The development allows adding booster fragments to finished pharmaceutical preparations. 22:15 10.01.2026 Vremya N - Nizhny Novgorod

      NNSU scientists have developed a method to enhance antitumor drugs

      The technology features high productivity.

      NNSU scientists have created a new chemical technique that allows increasing the effectiveness of existing antitumor drugs. 16:14 10.01.2026 Newsroom24.Ru - Nizhny Novgorod

      Nizhny Novgorod scientists have developed a way to enhance antitumor drugs

      14:32 10 January

      Anna Vasilyeva

      photo from the "Pro Gorod" archive

      Scientists of Lobachevsky University in Nizhny Novgorod have developed a new way to improve antitumor drugs. 14:52 10.01.2026 ProGorodNN.Ru - Nizhny Novgorod

      Nizhny Novgorod scientists have developed a method to enhance antitumor drugs

      Scientists from Lobachevsky University in Nizhny Novgorod have come up with how to make antitumor medicines stronger. 14:26 10.01.2026 Nizhegorodskaya Pravda - Nizhny Novgorod

      NNSU scientists found a way to increase the effectiveness of antitumor drugs

      Photo: press service of Nizhny Novgorod State University named after N.I. Lobachevsky (NNSU), author - Andrey Skvortsov

      At NNSU... 14:21 10.01.2026 NIA Nizhny Novgorod - Nizhny Novgorod

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      Photo: Main Directorate of the Ministry of Internal Affairs of Russia for the Nizhny Novgorod Region

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