Scientists at Nizhny Novgorod State University have developed a nanocomplex to address selenium deficiency.

      September 15, 2025 16:38

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      Science. Chemists at Lobachevsky University have developed a nontoxic biocompatible composition based on nanoselenium and chitosan that can be used in safe and effective dietary supplements.

      As explained at Nizhny Novgorod State University (NNSU), selenium nanoparticles combined with the natural polymer chitosan have antioxidant properties and are well absorbed by the body. The development will help address the deficiency of the trace element, which is particularly relevant in regions of Russia with selenium-poor soils.

      "Selenium affects the condition of the skin and hair, the function of the heart, blood vessels and the reproductive system. A deficiency of this micronutrient can lead to serious disorders in the body," said Kristina Apryatina, an associate professor in the Department of High-Molecular Compounds and Colloid Chemistry at NNSU.

      Currently, in most dietary supplements selenium is present in ionic form, which is less well absorbed. To obtain the required dose, its concentration in preparations must be increased. In nanoform the micronutrient acts more effectively and is less toxic, and chitosan helps retain it and deliver it to the target organs.

      "Chitosan not only stabilizes the nanoparticles, but is also beneficial in itself. It has antitumor and anti-inflammatory properties, aids tissue regeneration and has antioxidant effects. Together with selenium they are capable of slowing down aging processes," Apryatina noted.

      Scientists are also studying the ability of nanoselenium to improve oxygen uptake under hypoxic conditions, for example in the mountains. In the future, chitosan is planned to be used as a carrier for other trace elements such as zinc and copper.

      The development was carried out at the Faculty of Chemistry of N.I. Lobachevsky Nizhny Novgorod State University and patented with the support of the university’s Technology Transfer Center. The research was implemented as part of a project of the Russian Science Foundation’s Presidential Program to support scientific projects.

      Earlier it was reported that NNSU scientists developed new catalysts for green chemistry and pharmaceuticals.

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